Reaction Details Report a problem with these data
Target
Tubulin beta-2B chain
Ligand
BDBM50041119
Substrate
n/a
Meas. Tech.
ChEMBL_211333 (CHEMBL820776)
IC50
850.0±n/a nM
Citation
 Li, L; Wang, HK; Kuo, SC; Wu, TS; Lednicer, D; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 37:1126-35 (1994) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50041119
Synonyms:
2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one | 6-(2-Fluoro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | 6-(2-fluorophenyl)-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one | CHEMBL280099 | NSC-656158
Type:
Small organic molecule
Emp. Form.:
C16H10FNO3
Mol. Mass.:
283.2539
SMILES:
Oc1cc(nc2cc3OCOc3cc12)-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: