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Target
Tubulin beta-2B chain
Ligand
BDBM50005478
Substrate
n/a
Meas. Tech.
ChEMBL_211333 (CHEMBL820776)
IC50
630±n/a nM
Citation
 Li, L; Wang, HK; Kuo, SC; Wu, TS; Lednicer, D; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 37:1126-35 (1994) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50005478
Synonyms:
2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-phenol | 2-methoxy-5-(3,4,5-trimethoxyphenethyl)phenol | CHEMBL10557
Type:
Small organic molecule
Emp. Form.:
C18H22O5
Mol. Mass.:
318.3643
SMILES:
COc1ccc(CCc2cc(OC)c(OC)c(OC)c2)cc1O
Structure:
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