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Target
Tubulin beta-2B chain
Ligand
BDBM50041139
Substrate
n/a
Meas. Tech.
ChEMBL_211333 (CHEMBL820776)
IC50
>40000±n/a nM
Citation
 Li, L; Wang, HK; Kuo, SC; Wu, TS; Lednicer, D; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 37:1126-35 (1994) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50041139
Synonyms:
2-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-1H-quinolin-4-one | CHEMBL443474
Type:
Small organic molecule
Emp. Form.:
C19H19NO5
Mol. Mass.:
341.3579
SMILES:
COc1ccc(cc1OC)-c1cc(O)c2cc(OC)c(OC)cc2n1
Structure:
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