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Target
Dihydrofolate reductase
Ligand
BDBM50041178
Substrate
n/a
Meas. Tech.
ChEMBL_53004 (CHEMBL664434)
IC50
>35000±n/a nM
Citation
 Gangjee, A; Devraj, R; McGuire, JJ; Kisliuk, RL; Queener, SF; Barrows, LR Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. J Med Chem 37:1169-76 (1994) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50041178
Synonyms:
5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine | 5-[(3,4-Dichloro-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL274278
Type:
Small organic molecule
Emp. Form.:
C13H11Cl2N5O
Mol. Mass.:
324.165
SMILES:
Nc1nc(N)c2c(CNc3ccc(Cl)c(Cl)c3)coc2n1
Structure:
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