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Target
Reverse transcriptase
Ligand
BDBM50494905
Substrate
n/a
Meas. Tech.
ChEMBL_1281575 (CHEMBL3102260)
IC50
4.3±n/a nM
Citation
 Iyidogan, P; Sullivan, TJ; Chordia, MD; Frey, KM; Anderson, KS Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase. ACS Med Chem Lett 4:1183-8 (2013) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50494905
Synonyms:
CHEMBL3099595
Type:
Small organic molecule
Emp. Form.:
C39H44N7O9P
Mol. Mass.:
785.7819
SMILES:
Cc1cc(cc(C)c1Oc1ccnc(Nc2ccc(cc2)C#N)n1)C#CCCCCCCCC(=O)NCc1cn([C@H]2C[C@H](O)[C@@H](COP(O)=O)O2)c(=O)[nH]c1=O |r|
Structure:
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