Reaction Details Report a problem with these data
Target
Signal peptidase I
Ligand
BDBM50441139
Substrate
n/a
Meas. Tech.
ChEMBL_1285777 (CHEMBL3107901)
Kd
39±n/a nM
Citation
 Brown, DG; Lister, T; May-Dracka, TL New natural products as new leads for antibacterial drug discovery. Bioorg Med Chem Lett 24:413-8 (2014) [PubMed]  Article 
Target
Name:
Signal peptidase I
Synonyms:
LEP_ECOLI | Leader peptidase I | SPase I | lepB
Type:
PROTEIN
Mol. Mass.:
35961.43
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_154169
Residue:
324
Sequence:
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGLRLSRIGGIH
  
Inhibitor
Name:
BDBM50441139
Synonyms:
ARYLOMYCIN C16
Type:
Small organic molecule
Emp. Form.:
C46H68N6O11
Mol. Mass.:
881.0657
SMILES:
CCCCCCCCCCCCCCCC(=O)N(C)[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@H]1c2ccc(O)c(c2)-c2cc(C[C@H](NC(=O)[C@H](C)NC1=O)C(O)=O)ccc2O |r|
Structure:
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