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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50495323
Substrate
n/a
Meas. Tech.
ChEMBL_1283917 (CHEMBL3106530)
Ki
358±n/a nM
Citation
 Szermerski, M; Melesina, J; Wichapong, K; Löppenberg, M; Jose, J; Sippl, W; Holl, R Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. Bioorg Med Chem 22:1016-28 (2014) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM50495323
Synonyms:
CHEMBL3103548
Type:
Small organic molecule
Emp. Form.:
C24H28N2O6
Mol. Mass.:
440.4889
SMILES:
OC[C@H](O[C@H](CO)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO |r|
Structure:
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