Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50495635
Substrate
n/a
Meas. Tech.
ChEMBL_1291676 (CHEMBL3119423)
Ki
>10000±n/a nM
Citation
 Lucchesi, V; Parkkari, T; Savinainen, JR; Malfitano, AM; Allarà, M; Bertini, S; Castelli, F; Del Carlo, S; Laezza, C; Ligresti, A; Saccomanni, G; Bifulco, M; Di Marzo, V; Macchia, M; Manera, C 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. Eur J Med Chem 74:524-32 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50495635
Synonyms:
CHEMBL3114176
Type:
Small organic molecule
Emp. Form.:
C15H22N2O3
Mol. Mass.:
278.3468
SMILES:
CC1CCC(CC1)NC(=O)c1cccn(CCO)c1=O |(41.43,-45.3,;39.89,-45.3,;39.12,-43.97,;37.58,-43.97,;36.81,-45.3,;37.58,-46.64,;39.12,-46.64,;35.27,-45.3,;34.5,-46.64,;35.27,-47.97,;32.96,-46.64,;32.19,-47.97,;30.65,-47.97,;29.88,-46.64,;30.65,-45.3,;29.88,-43.97,;28.34,-43.97,;27.57,-42.63,;32.19,-45.3,;32.96,-43.97,)|
Structure:
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