Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50495644
Substrate
n/a
Meas. Tech.
ChEMBL_1291676 (CHEMBL3119423)
Ki
583±n/a nM
Citation
 Lucchesi, V; Parkkari, T; Savinainen, JR; Malfitano, AM; Allarà, M; Bertini, S; Castelli, F; Del Carlo, S; Laezza, C; Ligresti, A; Saccomanni, G; Bifulco, M; Di Marzo, V; Macchia, M; Manera, C 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. Eur J Med Chem 74:524-32 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50495644
Synonyms:
CHEMBL3114174
Type:
Small organic molecule
Emp. Form.:
C16H24N2O2
Mol. Mass.:
276.374
SMILES:
CCCn1cccc(C(=O)NC2CCC(C)CC2)c1=O |(28.49,-35.31,;29.26,-36.65,;30.8,-36.65,;31.57,-37.99,;30.8,-39.31,;31.57,-40.65,;33.11,-40.65,;33.88,-39.31,;35.42,-39.31,;36.19,-40.65,;36.19,-37.99,;37.73,-37.99,;38.5,-36.65,;40.04,-36.65,;40.81,-37.98,;42.35,-37.98,;40.04,-39.31,;38.5,-39.31,;33.11,-37.99,;33.88,-36.65,)|
Structure:
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