Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50495641
Substrate
n/a
Meas. Tech.
ChEMBL_1291676 (CHEMBL3119423)
Ki
594±n/a nM
Citation
 Lucchesi, V; Parkkari, T; Savinainen, JR; Malfitano, AM; Allarà, M; Bertini, S; Castelli, F; Del Carlo, S; Laezza, C; Ligresti, A; Saccomanni, G; Bifulco, M; Di Marzo, V; Macchia, M; Manera, C 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor. Eur J Med Chem 74:524-32 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50495641
Synonyms:
CHEMBL3114347
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2
Mol. Mass.:
324.4168
SMILES:
CC1CCC(CC1)NC(=O)c1cccnc1OCc1ccccc1 |(17.09,-54.87,;17.86,-53.54,;17.09,-52.2,;17.86,-50.86,;19.4,-50.87,;20.18,-52.2,;19.41,-53.54,;20.17,-49.53,;19.4,-48.18,;17.85,-48.18,;20.17,-46.85,;19.4,-45.51,;20.17,-44.17,;21.72,-44.17,;22.49,-45.51,;21.72,-46.85,;22.49,-48.18,;24.03,-48.18,;24.79,-49.52,;24.02,-50.84,;24.79,-52.17,;26.32,-52.17,;27.09,-50.83,;26.32,-49.51,)|
Structure:
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