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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50170158
Substrate
n/a
Meas. Tech.
ChEMBL_1294039 (CHEMBL3122550)
Ki
21±n/a nM
Citation
 Sagnes, C; Fournet, G; Satala, G; Bojarski, AJ; Joseph, B New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies. Eur J Med Chem 75:159-68 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50170158
Synonyms:
1-(2-Methoxy-phenyl)-4-(1-o-tolyl-1H-pyrrol-3-ylmethyl)-piperazine | 1-(2-methoxyphenyl)-4-((1-o-tolyl-1H-pyrrol-3-yl)methyl)piperazine | CHEMBL177064
Type:
Small organic molecule
Emp. Form.:
C23H27N3O
Mol. Mass.:
361.48
SMILES:
COc1ccccc1N1CCN(Cc2ccn(c2)-c2ccccc2C)CC1
Structure:
Search PDB for entries with ligand similarity: