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Target
Cytochrome P450 2C11
Ligand
BDBM50189778
Substrate
n/a
Meas. Tech.
ChEMBL_1328815 (CHEMBL3227399)
EC50
7700±n/a nM
Citation
 Englund, EE; Neumann, S; Eliseeva, E; McCoy, JG; Titus, S; Zheng, W; Southall, N; Shin, P; Leister, W; Thomas, CJ; Inglese, J; Austin, CP; Gershengorn, MC; Huang, W The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm 2:1016-1020 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C11
Synonyms:
CP2CB_RAT | Cyp2c | Cyp2c-11 | Cyp2c11
Type:
PROTEIN
Mol. Mass.:
57187.48
Organism:
Rattus norvegicus
Description:
ChEMBL_100121
Residue:
500
Sequence:
MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL
  
Inhibitor
Name:
BDBM50189778
Synonyms:
CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide | ORG-41841 | cid_9887381
Type:
Small organic molecule
Emp. Form.:
C19H22N4O2S2
Mol. Mass.:
402.534
SMILES:
COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Structure:
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