Reaction Details Report a problem with these data
Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50497010
Substrate
n/a
Meas. Tech.
ChEMBL_1337537 (CHEMBL3242296)
IC50
16000±n/a nM
Citation
 Niu, S; Liu, D; Hu, X; Proksch, P; Shao, Z; Lin, W Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. J Nat Prod 77:1021-30 (2014) [PubMed]  Article 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
  
Inhibitor
Name:
BDBM50497010
Synonyms:
CHEMBL3234398
Type:
Small organic molecule
Emp. Form.:
C19H17Cl3O5
Mol. Mass.:
431.694
SMILES:
CCCc1cc(O)c(Cl)c2OC(=O)c3c(CCC)c(Cl)c(O)c(Cl)c3Oc12
Structure:
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