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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM83720
Substrate
n/a
Meas. Tech.
ChEMBL_1341502 (CHEMBL3254080)
IC50
0.020±n/a nM
Citation
 Elslager, EF; Hutt, MP; Jacob, P; Johnson, J; Temporelli, B; Werbel, LM; Worth, DF; Rane, L Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. J Med Chem 22:1247-57 (1979) [PubMed]  Article 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
  
Inhibitor
Name:
BDBM83720
Synonyms:
6-(2-naphthalenylsulfonyl)quinazoline-2,4-diamine | 6-naphthalen-2-ylsulfonylquinazoline-2,4-diamine | MLS002920661 | SMR001798248 | WR 158122 | [2-amino-6-(2-naphthylsulfonyl)quinazolin-4-yl]amine | cid_98652
Type:
Small organic molecule
Emp. Form.:
C18H14N4O2S
Mol. Mass.:
350.394
SMILES:
Nc1nc(N)c2cc(ccc2n1)S(=O)(=O)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: