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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50497194
Substrate
n/a
Meas. Tech.
ChEMBL_1361525 (CHEMBL3294849)
IC50
1440±n/a nM
Citation
 Pereira, UA; Barbosa, LC; Maltha, CR; Demuner, AJ; Masood, MA; Pimenta, AL Inhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogues of rubrolides. Eur J Med Chem 82:127-38 (2014) [PubMed]  Article 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
  
Inhibitor
Name:
BDBM50497194
Synonyms:
CHEMBL3116168
Type:
Small organic molecule
Emp. Form.:
C22H20Br2ClNO2
Mol. Mass.:
525.661
SMILES:
COc1ccc(Cl)cc1C1=C(Br)C(=O)N(CC(C)C)\C1=C\c1ccccc1Br |c:10|
Structure:
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