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Target
Ribonucleoside-diphosphate reductase large subunit/subunit M2 B
Ligand
BDBM50497567
Substrate
n/a
Meas. Tech.
ChEMBL_1431546 (CHEMBL3390467)
Ki
400000±n/a nM
Citation
 Petrelli, R; Meli, M; Vita, P; Torquati, I; Ferro, A; Vodnala, M; D'Alessandro, N; Tolomeo, M; Del Bello, F; Kusumanchi, P; Franchetti, P; Grifantini, M; Jayaram, HN; Hofer, A; Cappellacci, L From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. Bioorg Med Chem Lett 24:5304-9 (2014) [PubMed]  Article 
Target
Name:
Ribonucleoside-diphosphate reductase large subunit/subunit M2 B
Synonyms:
Ribonucleoside-diphosphate reductase M1 chain/Ribonucleotide reductase | Ribonucleotide reductase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 745616
Components:
This complex has 2 components.
Component 1
Name:
Ribonucleoside-diphosphate reductase large subunit
Synonyms:
RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit
Type:
PROTEIN
Mol. Mass.:
90074.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90946
Residue:
792
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
  
Component 2
Name:
Ribonucleoside-diphosphate reductase subunit M2 B
Synonyms:
P53R2 | RIR2B_HUMAN | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | Ribonucleotide reductase | TP53-inducible ribonucleotide reductase M2 B | p53-inducible ribonucleotide reductase small subunit 2-like protein
Type:
PROTEIN
Mol. Mass.:
40721.91
Organism:
Homo sapiens (Human)
Description:
EBI_318
Residue:
351
Sequence:
MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
  
Inhibitor
Name:
BDBM50497567
Synonyms:
CHEMBL3337770
Type:
Small organic molecule
Emp. Form.:
C19H29N5O5
Mol. Mass.:
407.4641
SMILES:
CCCC(CCC)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@]1(C)O)n1cnc2c(N)ncnc12 |r|
Structure:
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