Reaction Details Report a problem with these data
Target
Elastase
Ligand
BDBM50241254
Substrate
n/a
Meas. Tech.
ChEMBL_1442820 (CHEMBL3376525)
IC50
400±n/a nM
Citation
Adekoya, OA; Sjøli, S; Wuxiuer, Y; Bilto, I; Marques, SM; Santos, MA; Nuti, E; Cercignani, G; Rossello, A; Winberg, JO; Sylte, I Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors. Eur J Med Chem 89:340-8 (2015) [PubMed] Article
More Info.:
Target
Name:
Elastase
Synonyms:
ELAS_PSEAE | Pseudolysin | lasB
Type:
PROTEIN
Mol. Mass.:
53687.94
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_619859
Residue:
498
Sequence:
MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
Inhibitor
Name:
BDBM50241254
Synonyms:
2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide | CHEMBL234737 | N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
Type:
Small organic molecule
Emp. Form.:
C19H24N4O5S
Mol. Mass.:
420.483
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)Cc2ccccc2)cc1