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Target
G-protein coupled receptor homolog US28
Ligand
BDBM50027216
Substrate
n/a
Meas. Tech.
ChEMBL_1455744 (CHEMBL3366772)
EC50
4571±n/a nM
Citation
 Tschammer, N Allosteric modulation of the G protein-coupled US28 receptor of human cytomegalovirus: are the small-weight inverse agonist of US28 'camouflaged' agonists? Bioorg Med Chem Lett 24:3744-7 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled receptor homolog US28
Synonyms:
Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA
Type:
PROTEIN
Mol. Mass.:
41070.46
Organism:
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:
ChEMBL_322135
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
  
Inhibitor
Name:
BDBM50027216
Synonyms:
5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile | 5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile | CHEMBL34166 | VUF-2274
Type:
Small organic molecule
Emp. Form.:
C28H29ClN2O
Mol. Mass.:
444.996
SMILES:
OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Structure:
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