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Target
Dual specificity mitogen-activated protein kinase kinase 1/2
Ligand
BDBM50498018
Substrate
n/a
Meas. Tech.
ChEMBL_1455795 (CHEMBL3361507)
IC50
97±n/a nM
Citation
 Redwan, IN; Dyrager, C; Solano, C; Fernández de Trocóniz, G; Voisin, L; Bliman, D; Meloche, S; Grøtli, M Towards the development of chromone-based MEK1/2 modulators. Eur J Med Chem 85:127-38 (2014) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1/2
Synonyms:
Dual specificity mitogen-activated protein kinase kinase MEK1/2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1455795
Components:
This complex has 2 components.
Component 1
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
2.7.12.2 | Dual specificity mitogen-activated protein kinase kinase 1 | ERK activator kinase 1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | MAPKK 1 | MEK 1 | MP2K1_RAT | Map2k1 | Mek1 | Prkmk1
Type:
PROTEIN
Mol. Mass.:
43465.04
Organism:
Rattus norvegicus
Description:
ChEMBL_109633
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
  
Component 2
Name:
Dual specificity mitogen-activated protein kinase kinase 2
Synonyms:
2.7.12.2 | Dual specificity mitogen-activated protein kinase kinase 2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK 2 | MP2K2_RAT | Map2k2 | Mek2 | Mkk2 | Prkmk2
Type:
PROTEIN
Mol. Mass.:
44284.85
Organism:
Rattus norvegicus
Description:
ChEMBL_109633
Residue:
400
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV
  
Inhibitor
Name:
BDBM50498018
Synonyms:
CHEMBL3326331
Type:
Small organic molecule
Emp. Form.:
C19H20N2O4
Mol. Mass.:
340.3731
SMILES:
COc1cccc(c1N)-c1cc(=O)c2cccc(NCCCO)c2o1
Structure:
Search PDB for entries with ligand similarity: