Reaction Details Report a problem with these data
Target
Aromatic-L-amino-acid decarboxylase
Ligand
BDBM50046351
Substrate
n/a
Meas. Tech.
ChEMBL_36194 (CHEMBL649363)
Ki
24300±n/a nM
Citation
 Zembower, DE; Gilbert, JA; Ames, MM Enantiospecific syntheses of alpha-(fluoromethyl)tryptophan analogues: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase. J Med Chem 36:305-13 (1993) [PubMed]  Article 
Target
Name:
Aromatic-L-amino-acid decarboxylase
Synonyms:
DDC_MOUSE | DOPA decarboxylase | Ddc
Type:
PROTEIN
Mol. Mass.:
53874.00
Organism:
Mus musculus
Description:
ChEMBL_1333664
Residue:
480
Sequence:
MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRPLIPATAPQEPETYEDIIKDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKVIRQLQAASPEFTQAAIMEKLVAYTSDQAHSSVERAGLIGGIKLKAVPSDGNFSMRASALREALERDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRTDLTGAFNMDPVYLKHSHQDSGFITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVELSHEFESLVRQDPRFEICTEVILGLVCFRLKGSNELNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCARTVESAHVQLAWEHISDLASSVLRAEKE
  
Inhibitor
Name:
BDBM50046351
Synonyms:
2-Amino-2-fluoromethyl-3-(5-hydroxy-1H-indol-3-yl)-propionic acid | CHEMBL108478
Type:
Small organic molecule
Emp. Form.:
C12H13FN2O3
Mol. Mass.:
252.2416
SMILES:
N[C@@](CF)(Cc1c[nH]c2ccc(O)cc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: