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Target
REST corepressor 1
Ligand
BDBM50498147
Substrate
n/a
Meas. Tech.
ChEMBL_1467488 (CHEMBL3411111)
IC50
101±n/a nM
Citation
 Pieroni, M; Annunziato, G; Azzali, E; Dessanti, P; Mercurio, C; Meroni, G; Trifiró, P; Vianello, P; Villa, M; Beato, C; Varasi, M; Costantino, G Further insights into the SAR of ?-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. Eur J Med Chem 92:377-86 (2015) [PubMed]  Article 
Target
Name:
REST corepressor 1
Synonyms:
KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:
PROTEIN
Mol. Mass.:
53329.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108118
Residue:
485
Sequence:
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
  
Inhibitor
Name:
BDBM50498147
Synonyms:
CHEMBL3407604
Type:
Small organic molecule
Emp. Form.:
C17H19BrClN
Mol. Mass.:
352.696
SMILES:
Cl.N[C@@]1(CCc2ccccc2)C[C@@H]1c1ccc(Br)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: