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Target
Myc proto-oncogene protein/Protein max
Ligand
BDBM50498222
Substrate
n/a
Meas. Tech.
ChEMBL_1476091 (CHEMBL3428721)
Kd
13000±n/a nM
Citation
 Jung, KY; Wang, H; Teriete, P; Yap, JL; Chen, L; Lanning, ME; Hu, A; Lambert, LJ; Holien, T; Sundan, A; Cosford, ND; Prochownik, EV; Fletcher, S Perturbation of the c-Myc-Max protein-protein interaction via synthetic ?-helix mimetics. J Med Chem 58:3002-24 (2015) [PubMed]  Article 
Target
Name:
Myc proto-oncogene protein/Protein max
Synonyms:
c-Myc/Max
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1882034
Components:
This complex has 2 components.
Component 1
Name:
Myc proto-oncogene protein
Synonyms:
BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64
Type:
PROTEIN
Mol. Mass.:
48794.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_935266
Residue:
439
Sequence:
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
  
Component 2
Name:
Protein max
Synonyms:
BHLHD4 | Class D basic helix-loop-helix protein 4 | MAX | MAX_HUMAN | Myc-associated factor X
Type:
PROTEIN
Mol. Mass.:
18273.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_935265
Residue:
160
Sequence:
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
  
Inhibitor
Name:
BDBM50498222
Synonyms:
CHEMBL3427045
Type:
Small organic molecule
Emp. Form.:
C29H26N2O7
Mol. Mass.:
514.5259
SMILES:
CC(C)COc1cc(ccc1NC(=O)c1ccc(c(OCc2cccc3ccccc23)c1)[N+]([O-])=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: