Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50047069
Substrate
n/a
Meas. Tech.
ChEMBL_207650 (CHEMBL811632)
Ki
870.0±n/a nM
Citation
 Nicolaï, E; Goyard, J; Benchetrit, T; Teulon, JM; Caussade, F; Virone, A; Delchambre, C; Cloarec, A Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem 36:1175-87 (1993) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50047069
Synonyms:
CHEMBL275651 | {1-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2-ylmethyl]-cyclohexyl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN2O2
Mol. Mass.:
414.9
SMILES:
OC(=O)CC1(Cc2nc3cc(F)ccc3n2Cc2ccc(Cl)cc2)CCCCC1
Structure:
Search PDB for entries with ligand similarity: