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Target
Type-1 angiotensin II receptor
Ligand
BDBM50047111
Substrate
n/a
Meas. Tech.
ChEMBL_36780 (CHEMBL650301)
IC50
5±n/a nM
Citation
 Bradbury, RH; Allott, CP; Dennis, M; Girdwood, JA; Kenny, PW; Major, JS; Oldham, AA; Ratcliffe, AH; Rivett, JE; Roberts, DA New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives. J Med Chem 36:1245-54 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor
Type:
PROTEIN
Mol. Mass.:
41004.19
Organism:
Cavia porcellus
Description:
ChEMBL_36783
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
  
Inhibitor
Name:
BDBM50047111
Synonyms:
6-Ethyl-2-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-nicotinic acid methyl ester | CHEMBL283742
Type:
Small organic molecule
Emp. Form.:
C24H23N5O3
Mol. Mass.:
429.4711
SMILES:
CCc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(C(=O)OC)c(C)n1
Structure:
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