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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50498624
Substrate
n/a
Meas. Tech.
ChEMBL_1512605 (CHEMBL3610652)
IC50
20±n/a nM
Citation
 Zou, Y; Qin, X; Hao, X; Zhang, W; Yang, S; Yang, Y; Han, Z; Ma, B; Zhu, C Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity. Bioorg Med Chem Lett 25:3924-7 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50498624
Synonyms:
CHEMBL3609180
Type:
Small organic molecule
Emp. Form.:
C16H11FN2O5
Mol. Mass.:
330.2673
SMILES:
OC(=O)Cn1c2ccc(F)cc2nc(Oc2ccc(O)cc2)c1=O
Structure:
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