Reaction Details Report a problem with these data
Target
Thromboxane-A synthase
Ligand
BDBM50010960
Substrate
n/a
Meas. Tech.
ChEBML_207656
IC50
2.9±n/a nM
Citation
 Ohshima, E; Sato, H; Obase, H; Miki, I; Ishii, A; Kawakage, M; Shirakura, S; Karasawa, A; Kubo, K Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule. J Med Chem 36:1613-8 (1993) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50010960
Synonyms:
(E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid(CV-4151) | CHEMBL26820 | CV-4151
Type:
Small organic molecule
Emp. Form.:
C18H19NO2
Mol. Mass.:
281.349
SMILES:
OC(=O)CCCC\C=C(/c1ccccc1)c1cccnc1
Structure:
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