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Target
Puromycin-sensitive aminopeptidase
Ligand
BDBM50499709
Substrate
n/a
Meas. Tech.
ChEMBL_1543183 (CHEMBL3744907)
IC50
8530±n/a nM
Citation
 Aeluri, R; Ganji, RJ; Marapaka, AK; Pillalamarri, V; Alla, M; Addlagatta, A Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase. Eur J Med Chem 106:26-33 (2015) [PubMed]  Article 
Target
Name:
Puromycin-sensitive aminopeptidase
Synonyms:
Aminopeptidase | NPEPPS | PSA | PSA_HUMAN
Type:
PROTEIN
Mol. Mass.:
103262.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_160080
Residue:
919
Sequence:
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
  
Inhibitor
Name:
BDBM50499709
Synonyms:
CHEMBL3741560
Type:
Small organic molecule
Emp. Form.:
C33H33N3O2
Mol. Mass.:
503.634
SMILES:
CCOC(=O)C1=C(CC(N(C1c1ccccn1)c1ccc(C)cc1)c1ccccc1)Nc1ccc(C)cc1 |t:5|
Structure:
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