Reaction Details Report a problem with these data
Target
Legumain
Ligand
BDBM50499745
Substrate
n/a
Meas. Tech.
ChEMBL_1540559 (CHEMBL3744013)
IC50
23±n/a nM
Citation
Ness, KA; Eddie, SL; Higgins, CA; Templeman, A; D'Costa, Z; Gaddale, KK; Bouzzaoui, S; Jordan, L; Janssen, D; Harrison, T; Burkamp, F; Young, A; Burden, R; Scott, CJ; Mullan, PB; Williams, R Development of a potent and selective cell penetrant Legumain inhibitor. Bioorg Med Chem Lett 25:5642-5 (2015) [PubMed] Article
More Info.:
Target
Name:
Legumain
Synonyms:
3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1
Type:
n/a
Mol. Mass.:
49411.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
433
Sequence:
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY