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Target
Tumor necrosis factor
Ligand
BDBM50010981
Substrate
n/a
Meas. Tech.
ChEMBL_212395 (CHEMBL873375)
IC50
50000±n/a nM
Citation
 Cottam, HB; Shih, H; Tehrani, LR; Wasson, DB; Carson, DA Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem 39:2-9 (1996) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM50010981
Synonyms:
(Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one(Ro 20-1724) | 4-(3-Butyl-4-methoxy-benzyl)-imidazolidin-2-one | CHEMBL18701 | RO 20-1724 | Ro-20-1724
Type:
Small organic molecule
Emp. Form.:
C15H22N2O3
Mol. Mass.:
278.3468
SMILES:
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Structure:
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