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Target
Integrase
Ligand
BDBM50049177
Substrate
n/a
Meas. Tech.
ChEMBL_88593 (CHEMBL699985)
IC50
21400±n/a nM
Citation
 Eich, E; Pertz, H; Kaloga, M; Schulz, J; Fesen, MR; Mazumder, A; Pommier, Y (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. J Med Chem 39:86-95 (1996) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50049177
Synonyms:
(3R,4R)-3,4-Bis-(3,4-dihydroxy-benzyl)-dihydro-furan-2-one | (3R,4R)-3,4-bis(3,4-dihydroxybenzyl)dihydrofuran-2(3H)-one | CHEMBL369471
Type:
Small organic molecule
Emp. Form.:
C18H18O6
Mol. Mass.:
330.3319
SMILES:
Oc1ccc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O)c(O)c2)cc1O
Structure:
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