Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50115661
Substrate
n/a
Meas. Tech.
ChEMBL_1541051 (CHEMBL3744282)
IC50
8230±n/a nM
Citation
 Zwick, V; Nurisso, A; Simões-Pires, C; Bouchet, S; Martinet, N; Lehotzky, A; Ovadi, J; Cuendet, M; Blanquart, C; Bertrand, P Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. Bioorg Med Chem Lett 26:154-9 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50115661
Synonyms:
CHEMBL320497 | N,8-dihydroxy-8-(hydroxyamino)octanamide | N1,N8-dihydroxyoctanediamide | Octanedioic acid bis-hydroxyamide | Suberohydroxamic acid | Suberoic bis hydroxamic acid | Suberoyl bis hydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C8H16N2O4
Mol. Mass.:
204.2236
SMILES:
ONC(=O)CCCCCCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: