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Target
Lipoprotein lipase
Ligand
BDBM50500149
Substrate
n/a
Meas. Tech.
ChEMBL_1543489 (CHEMBL3750336)
EC50
5000±n/a nM
Citation
 Caraballo, R; Larsson, M; Nilsson, SK; Ericsson, M; Qian, W; Nguyen Tran, NP; Kindahl, T; Svensson, R; Saar, V; Artursson, P; Olivecrona, G; Enquist, PA; Elofsson, M Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. Eur J Med Chem 103:191-209 (2015) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
3.1.1.34 | LIPL_BOVIN | LPL
Type:
PROTEIN
Mol. Mass.:
53392.39
Organism:
Bos taurus
Description:
ChEMBL_17053
Residue:
478
Sequence:
MESKALLLLALSVCLQSLTVSRGGLVAADRITGGKDFRDIESKFALRTPEDTAEDTCHLIPGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGQDVAKFMNWMADEFNYPLGNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEALRVIAERGLGDVDQLVKCSHERSVHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNMGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESNTYTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLLYTEVDIGELLMLKLKWISDSYFSWSNWWSSPGFDIGKIRVKAGETQKKVIFCSREKMSYLQKGKSPVIFVKCHDKSLNRKSG
  
Inhibitor
Name:
BDBM50500149
Synonyms:
CHEMBL3747367
Type:
Small organic molecule
Emp. Form.:
C27H26N4O3
Mol. Mass.:
454.5203
SMILES:
Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3cc(ccc3n2)C(O)=O)cc1
Structure:
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