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Target
Ribonucleoside-diphosphate reductase large subunit
Ligand
BDBM50500165
Substrate
n/a
Meas. Tech.
ChEMBL_1543977 (CHEMBL3750222)
Kd
55290±n/a nM
Citation
 Ahmad, MF; Huff, SE; Pink, J; Alam, I; Zhang, A; Perry, K; Harris, ME; Misko, T; Porwal, SK; Oleinick, NL; Miyagi, M; Viswanathan, R; Dealwis, CG Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem 58:9498-509 (2015) [PubMed]  Article 
Target
Name:
Ribonucleoside-diphosphate reductase large subunit
Synonyms:
RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit
Type:
PROTEIN
Mol. Mass.:
90074.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90946
Residue:
792
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
  
Inhibitor
Name:
BDBM50500165
Synonyms:
CHEMBL3746526
Type:
Small organic molecule
Emp. Form.:
C24H32N2O5S
Mol. Mass.:
460.586
SMILES:
CCCOc1ccc(cc1NS(=O)(=O)\C=C\c1ccccc1)C(=O)OCCN(CC)CC
Structure:
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