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Target
Transcription factor 4
Ligand
BDBM32102
Substrate
n/a
Meas. Tech.
ChEMBL_1565175 (CHEMBL3782567)
IC50
800±n/a nM
Citation
 Radwan, AA; Al-Mohanna, F; Alanazi, FK; Manogaran, PS; Al-Dhfyan, A Target ?-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. Bioorg Med Chem Lett 26:1664-70 (2016) [PubMed]  Article 
Target
Name:
Transcription factor 4
Synonyms:
BHLHB19 | Class B basic helix-loop-helix protein 19 | ITF-2 | ITF2 | ITF2_HUMAN | Immunoglobulin transcription factor 2 | SEF-2 | SEF2 | SL3-3 enhancer factor 2 | TCF-4 | TCF4 | Transcription factor 4
Type:
PROTEIN
Mol. Mass.:
71315.43
Organism:
Homo sapiens
Description:
ChEMBL_117085
Residue:
667
Sequence:
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM
  
Inhibitor
Name:
BDBM32102
Synonyms:
1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000087831 | SMR000024051 | US9284299, PKF118-310 | US9738628, Compound PKF118-310 | cid_66541
Type:
Small organic molecule
Emp. Form.:
C7H7N5O2
Mol. Mass.:
193.1628
SMILES:
Cn1ncnc2c1nc(=O)n(C)c2=O
Structure:
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