Reaction Details Report a problem with these data
Target
Transcription factor 4
Ligand
BDBM50500849
Substrate
n/a
Meas. Tech.
ChEMBL_1565175 (CHEMBL3782567)
IC50
640±n/a nM
Citation
 Radwan, AA; Al-Mohanna, F; Alanazi, FK; Manogaran, PS; Al-Dhfyan, A Target ?-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. Bioorg Med Chem Lett 26:1664-70 (2016) [PubMed]  Article 
Target
Name:
Transcription factor 4
Synonyms:
BHLHB19 | Class B basic helix-loop-helix protein 19 | ITF-2 | ITF2 | ITF2_HUMAN | Immunoglobulin transcription factor 2 | SEF-2 | SEF2 | SL3-3 enhancer factor 2 | TCF-4 | TCF4 | Transcription factor 4
Type:
PROTEIN
Mol. Mass.:
71315.43
Organism:
Homo sapiens
Description:
ChEMBL_117085
Residue:
667
Sequence:
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM
  
Inhibitor
Name:
BDBM50500849
Synonyms:
CHEMBL3780110
Type:
Small organic molecule
Emp. Form.:
C34H35NO15
Mol. Mass.:
697.6394
SMILES:
CO[C@@H]1[C@@H](C)OC(NC2=CC(=O)c3c(O)c4C(=O)[C@]5(OC)[C@H](O)Cc6cc(C)c(C(=O)OC)c(O)c6[C@@]5(O)C(=O)c4cc3C2=O)[C@@H](OC)[C@H]1O |r,t:8|
Structure:
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