Reaction Details Report a problem with these data
Target
Transcription factor 4
Ligand
BDBM50500850
Substrate
n/a
Meas. Tech.
ChEMBL_1565175 (CHEMBL3782567)
IC50
3200±n/a nM
Citation
 Radwan, AA; Al-Mohanna, F; Alanazi, FK; Manogaran, PS; Al-Dhfyan, A Target ?-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. Bioorg Med Chem Lett 26:1664-70 (2016) [PubMed]  Article 
Target
Name:
Transcription factor 4
Synonyms:
BHLHB19 | Class B basic helix-loop-helix protein 19 | ITF-2 | ITF2 | ITF2_HUMAN | Immunoglobulin transcription factor 2 | SEF-2 | SEF2 | SL3-3 enhancer factor 2 | TCF-4 | TCF4 | Transcription factor 4
Type:
PROTEIN
Mol. Mass.:
71315.43
Organism:
Homo sapiens
Description:
ChEMBL_117085
Residue:
667
Sequence:
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM
  
Inhibitor
Name:
BDBM50500850
Synonyms:
CHEMBL261214
Type:
Small organic molecule
Emp. Form.:
C44H38O14
Mol. Mass.:
790.7641
SMILES:
COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(CC(C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(CC(C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O
Structure:
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