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Target
Tubulin beta chain
Ligand
BDBM50500878
Substrate
n/a
Meas. Tech.
ChEMBL_1572729 (CHEMBL3804017)
IC50
2.1±n/a nM
Citation
 Thomopoulou, P; Sachs, J; Teusch, N; Mariappan, A; Gopalakrishnan, J; Schmalz, HG New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology. ACS Med Chem Lett 7:188-91 (2016) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50500878
Synonyms:
CHEMBL3799906
Type:
Small organic molecule
Emp. Form.:
C32H32FN3O7
Mol. Mass.:
589.6108
SMILES:
COc1cc2CC[C@@H](c3cc(=O)c(OC)ccc3-c2c(OC)c1OC)n1cc(CCC(=O)OCc2ccc(F)cc2)nn1 |r|
Structure:
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