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Target
Tubulin beta chain
Ligand
BDBM50500879
Substrate
n/a
Meas. Tech.
ChEMBL_1572729 (CHEMBL3804017)
IC50
3.2±n/a nM
Citation
 Thomopoulou, P; Sachs, J; Teusch, N; Mariappan, A; Gopalakrishnan, J; Schmalz, HG New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology. ACS Med Chem Lett 7:188-91 (2016) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50500879
Synonyms:
CHEMBL3800118
Type:
Small organic molecule
Emp. Form.:
C37H42N4O9
Mol. Mass.:
686.7508
SMILES:
COc1cc2CC[C@@H](c3cc(=O)c(OC)ccc3-c2c(OC)c1OC)n1cc(COC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)nn1 |r|
Structure:
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