Reaction Details Report a problem with these data
Target
60 kDa heat shock protein, mitochondrial
Ligand
BDBM46190
Substrate
n/a
Meas. Tech.
ChEMBL_1578874 (CHEMBL3813272)
IC50
15000±n/a nM
Citation
 Abdeen, S; Salim, N; Mammadova, N; Summers, CM; Frankson, R; Ambrose, AJ; Anderson, GG; Schultz, PG; Horwich, AL; Chapman, E; Johnson, SM GroEL/ES inhibitors as potential antibiotics. Bioorg Med Chem Lett 26:3127-3134 (2016) [PubMed]  Article 
Target
Name:
60 kDa heat shock protein, mitochondrial
Synonyms:
3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein
Type:
PROTEIN
Mol. Mass.:
61050.41
Organism:
Homo sapiens
Description:
ChEMBL_117701
Residue:
573
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
  
Inhibitor
Name:
BDBM46190
Synonyms:
1-[2,3-bis(2-furanyl)-6-quinoxalinyl]-3-(2-hydroxyethyl)urea | 1-[2,3-bis(2-furyl)quinoxalin-6-yl]-3-(2-hydroxyethyl)urea | 1-[2,3-bis(furan-2-yl)quinoxalin-6-yl]-3-(2-hydroxyethyl)urea | MLS-0202056.0001 | cid_3157646
Type:
Small organic molecule
Emp. Form.:
C19H16N4O4
Mol. Mass.:
364.3547
SMILES:
OCCNC(=O)Nc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: