Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50502560
Substrate
n/a
Meas. Tech.
ChEMBL_1807839 (CHEMBL4307198)
Ki
686±n/a nM
Citation
 Zampieri, D; Fortuna, S; Calabretti, A; Romano, M; Menegazzi, R; Schepmann, D; Wünsch, B; Collina, S; Zanon, D; Mamolo, MG Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. Eur J Med Chem 180:268-282 (2019) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50502560
Synonyms:
CHEMBL4567801
Type:
Small organic molecule
Emp. Form.:
C22H25FN4O2
Mol. Mass.:
396.4579
SMILES:
Fc1ccc(cc1)N1CCN(CCCCn2nc(oc2=O)-c2ccccc2)CC1
Structure:
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