Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50502554
Substrate
n/a
Meas. Tech.
ChEMBL_1807838 (CHEMBL4307197)
Ki
60±n/a nM
Citation
 Zampieri, D; Fortuna, S; Calabretti, A; Romano, M; Menegazzi, R; Schepmann, D; Wünsch, B; Collina, S; Zanon, D; Mamolo, MG Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. Eur J Med Chem 180:268-282 (2019) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50502554
Synonyms:
CHEMBL4533030
Type:
Small organic molecule
Emp. Form.:
C23H30N2O
Mol. Mass.:
350.4971
SMILES:
CN(CCCCN1C(=O)CCc2ccccc12)Cc1ccc(C)cc1C
Structure:
Search PDB for entries with ligand similarity: