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Target
Serine/threonine-protein kinase VRK1
Ligand
BDBM25017
Substrate
n/a
Meas. Tech.
ChEMBL_1808292 (CHEMBL4307651)
IC50
33±n/a nM
Citation
 Serafim, RAM; de Souza Gama, FH; Dutra, LA; Dos Reis, CV; Vasconcelos, SNS; da Silva Santiago, A; Takarada, JE; Di Pillo, F; Azevedo, H; Mascarello, A; Elkins, JM; Massirer, KB; Gileadi, O; Guimarães, CRW; Couņago, RM Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett 10:1266-1271 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase VRK1
Synonyms:
VRK1 | VRK1_HUMAN | Vaccinia-related kinase 1
Type:
PROTEIN
Mol. Mass.:
45490.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1337676
Residue:
396
Sequence:
MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK
  
Inhibitor
Name:
BDBM25017
Synonyms:
2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one | BI-D1870 | US11851436, Compound BI-D1870
Type:
Small organic molecule
Emp. Form.:
C19H23F2N5O2
Mol. Mass.:
391.415
SMILES:
CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12
Structure:
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