Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50052853
Substrate
n/a
Meas. Tech.
ChEMBL_58799 (CHEMBL667041)
Ki
>2000±n/a nM
Citation
 Hedberg, MH; Jansen, JM; Nordvall, G; Hjorth, S; Unelius, L; Johansson, AM 10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions. J Med Chem 39:3491-502 (1996) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50052853
Synonyms:
CHEMBL334116 | Trifluoro-methanesulfonic acid (R)-11-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl ester
Type:
Small organic molecule
Emp. Form.:
C19H18F3NO4S
Mol. Mass.:
413.411
SMILES:
COc1c(OS(=O)(=O)C(F)(F)F)ccc2C[C@H]3N(C)CCc4cccc(c34)-c12
Structure:
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