Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50052867
Substrate
n/a
Meas. Tech.
ChEMBL_58661 (CHEMBL670435)
Ki
700±n/a nM
Citation
 Hedberg, MH; Linnanen, T; Jansen, JM; Nordvall, G; Hjorth, S; Unelius, L; Johansson, AM 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. J Med Chem 39:3503-13 (1996) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50052867
Synonyms:
(R)-6,11-Dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | 6,11-Dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | CHEMBL27940
Type:
Small organic molecule
Emp. Form.:
C18H19N
Mol. Mass.:
249.3502
SMILES:
CN1CCc2cccc-3c2[C@H]1Cc1cccc(C)c-31
Structure:
Search PDB for entries with ligand similarity: