Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50052889
Substrate
n/a
Meas. Tech.
ChEMBL_152389 (CHEMBL765512)
Ki
21300±n/a nM
Citation
 Grunewald, GL; Dahanukar, VH; Ching, P; Criscione, KR Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase. J Med Chem 39:3539-46 (1996) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50052889
Synonyms:
1,2,3,4,5,6-Hexahydro-benzo[c]azocine | CHEMBL116945
Type:
Small organic molecule
Emp. Form.:
C11H15N
Mol. Mass.:
161.2435
SMILES:
C1CCc2ccccc2CNC1
Structure:
Search PDB for entries with ligand similarity: