Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50053096
Substrate
n/a
Meas. Tech.
ChEMBL_156184 (CHEMBL760953)
IC50
5±n/a nM
Citation
 Hagishita, S; Yamada, M; Shirahase, K; Okada, T; Murakami, Y; Ito, Y; Matsuura, T; Wada, M; Kato, T; Ueno, M; Chikazawa, Y; Yamada, K; Ono, T; Teshirogi, I; Ohtani, M Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives. J Med Chem 39:3636-58 (1996) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM50053096
Synonyms:
CHEMBL123774 | [1-Aminooxalyl-3-(4-butyl-benzyl)-2-ethyl-indolizin-8-yloxy]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C25H28N2O5
Mol. Mass.:
436.5002
SMILES:
CCCCc1ccc(Cc2c(CC)c(C(=O)C(N)=O)c3c(OCC(O)=O)cccn23)cc1
Structure:
Search PDB for entries with ligand similarity: