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Target
Serine/threonine-protein kinase ULK2
Ligand
BDBM50503137
Substrate
n/a
Meas. Tech.
ChEMBL_1809524 (CHEMBL4308984)
IC50
1.1±n/a nM
Citation
 He, S; Li, Q; Jiang, X; Lu, X; Feng, F; Qu, W; Chen, Y; Sun, H Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy. J Med Chem 61:4656-4687 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ULK2
Synonyms:
KIAA0623 | ULK2 | ULK2_HUMAN | Unc-51-like kinase 2
Type:
PROTEIN
Mol. Mass.:
112726.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510276
Residue:
1036
Sequence:
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
  
Inhibitor
Name:
BDBM50503137
Synonyms:
CHEMBL4516990
Type:
Small organic molecule
Emp. Form.:
C25H34N6O
Mol. Mass.:
434.5771
SMILES:
CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
Structure:
Search PDB for entries with ligand similarity: