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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48044
Substrate
n/a
Meas. Tech.
ChEMBL_1810472 (CHEMBL4309932)
EC50
400±n/a nM
Citation
 Wold, EA; Chen, J; Cunningham, KA; Zhou, J Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. J Med Chem 62:88-127 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48044
Synonyms:
3-amino-4,6-dimethyl-N-piperonyl-thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide | VU0152099-1 | cid_1541501
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3S
Mol. Mass.:
355.411
SMILES:
Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: