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Target
Carbonic anhydrase 7
Ligand
BDBM50503816
Substrate
n/a
Meas. Tech.
ChEMBL_1812152 (CHEMBL4311612)
Kd
0.017000±n/a nM
Citation
 Va?kevi?ien?, I; Paketuryt?, V; Pajanok, N; ?ukauskas, ?; Sapijanskait?, B; Kantminien?, K; Mickevi?ius, V; Zubrien?, A; Matulis, D Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases. Bioorg Med Chem 27:322-337 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50503816
Synonyms:
CHEMBL4573916
Type:
Small organic molecule
Emp. Form.:
C20H20Cl2N4O4S
Mol. Mass.:
483.368
SMILES:
Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(Cl)cc2)c(Cl)c(C)c1S(N)(=O)=O
Structure:
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