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Target
Protein mono-ADP-ribosyltransferase PARP8
Ligand
BDBM50503853
Substrate
n/a
Meas. Tech.
ChEMBL_1812388 (CHEMBL4311848)
IC50
>30000±n/a nM
Citation
 Morgan, RK; Kirby, IT; Vermehren-Schmaedick, A; Rodriguez, K; Cohen, MS Rational Design of Cell-Active Inhibitors of PARP10. ACS Med Chem Lett 10:74-79 (2019) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP8
Synonyms:
2.4.2.- | ADP-ribosyltransferase diphtheria toxin-like 16 | ARTD16 | PARP-8 | PARP8 | PARP8_HUMAN | Poly [ADP-ribose] polymerase 8 | Protein mono-ADP-ribosyltransferase PARP8
Type:
PROTEIN
Mol. Mass.:
95895.03
Organism:
Homo sapiens
Description:
ChEMBL_107973
Residue:
854
Sequence:
MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVTKSHRTFGRSLSSDPRAEQAMTAIKSHKLLNRPCPAAVKSEECLTLKSHRLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNAEGRRLSLTSGLIGILTPSSSSSSQLAPNGAKCIPVRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFLQSRNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG
  
Inhibitor
Name:
BDBM50503853
Synonyms:
CHEMBL4545565
Type:
Small organic molecule
Emp. Form.:
C16H13F3N2O
Mol. Mass.:
306.2824
SMILES:
Cc1c2CCNC(=O)c2ccc1-c1ccnc(c1)C(F)(F)F
Structure:
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